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Giosuè Gulli

Neurologo

Curriculum vitae:

Laurea in Medicina e Chirurgia presso l’Università degli Studi di Verona (1996)
Dottore di Ricerca in Fisiologia (PhD) - Università degli Studi di Verona e Torino (2001). Tesi di dottorato: “Studio delle oscillazioni spontanee nel sistema cardiovascolare. Interpretazioni fisiologiche ed applicazioni nello studio della sincope.” Relatore: Prof Cevese Antonio.
Diploma di Specializzazione in Neurologia - Università degli Studi di Verona (2001-2006). Tesi di Specialità: “effetti della stimolazione magnetica transcranica ripetitiva sull’attività del Sistema Nervoso Autonomo”. Relatore: Prof Nicolò Rizzuto-Dr Giuseppe Bongiovanni
2001 - 2003 Clinica Neurologica presso l’Università di Erlangen-Nurnmberg, Germania. Direttore Prof Berndt Neundorfer. Rotazioni in: Stroke Unit - Terapia Intensiva Neurologica - Neurofisiologia - Centro Epilessia
2003 - 2005 Clinica Neurologica presso Leeds Teaching Hospitals, Leeds, Inghilterra. Direttore: Dr John Bamford. Rotazioni in Reparto Neurologia - Stroke unit - Ambulatori di Neurologia generale
2005 - 2006 Clinica Neurologica presso l’Università degli Studi di Verona, Italia. Direttore: Prof Nicolò Rizzuto. Rotazioni in Reparto Neurologia - Ambulatori di Epilessia e Sistema Nervoso Autonomo
2006 - 2007 Dirigente di Primo livello a tempo determinato presso il Dipartimento di Medicina (Unità Stroke Unit) dell’Ospedale Regionale di Bolzano. Direttore: Dr M. Marchesi
2007 - 2008 Clinical Research Fellow in Stroke Medicine. Coordinatore Prof Hugh Markus
2008 - 2013 Medico specialista a contratto e in seguito Dirigente Medico di primo livello a tempo indeterminato presso la U.O di Neurologia dell’Azienda Ospedaliera Universitaria Integrata di Verona. Direttore: Dr G. Moretto
2013 - 2014 Fixed term Neurology Consultant and Consultant Stroke Physician, St George’s Hospital NHS Foundation Trust, London. Equivalente di Dirigente Medico Specialista in Neurologia a tempo determinato.
2014 - 2016 Permanent Neurology Consultant and Consultant Stroke Physician, Frimley Park NHS Foundation Trust. Equivalente di Dirigente Medico Specialista in Neurologia a tempo indeterminato.
2017 - 2021 Permanent Neurology Consultant and Consultant Stroke Physician. Clinical Lead of the Stroke Medicine Department.. Ashford and St Peter’s Hospitals NHS Trust
2021 - 2022. Permanent Neurology Consultant and Consultant Stroke Physician. Clinical Lead of the Stroke telemedicine service in Surrey. East Surrey and Sussex Foundation Trust
2022 ad oggi. Neurology Consultant and Consultant Stroke Physician.
Ashford and St Peter’s Hospitals NHS Trust
Clinical Research Fellowship in Stroke Medicine - 2007-2008. Coordinatore Prof Hugh Markus
Coordinatore dello Studio osservazionale nella popolazione di origine caraibica e afro-caraibica residente a Londra (SLESS study)
Studio epidemiologico e di immagini degli ictus del circolo posteriore (St George’s Stroke register)
29 ingressi a chiamata per lo sviluppo del laboratorio del sistema Neurovegetativo presso il Dipartimento di Medicina Interna, Ospedale Regionale di Bolzano. Direttore: Dr. Mario Marchesi
Nel periodo 2008 - 2013 prestazioni a chiamata fine settimanali con frequenza 1:8 come Honorary Stroke Consultant, St George’s Hospital NHS Foundation Trust, London - equivalente di Dirigente Medico a chiamata
Attività di Consulenza Medica per conto dell’azienda Ospedaliera di Verona in relazione allo sviluppo del servizio di telemedicina nella Regione Veneto. Progetto Health Optimum
Attività di Consulenza Medica per conto della Bayer per lo sviluppo dei percorsi clinici-diagnostici degli ictus embolici di origine indeterminata
Revisore del rischio clinico e della Governance in merito ai decessi ospedalieri occorsi al St Peter’s Hospital
Supervisor clinico e supervisor didattico di numerosi medici in formazione specialistica frequentanti il reparto Responsabile scientifico (Principal Investigator) di numerosi studi clinici

Clinical Fellowship in Stroke Medicine - St George’s University of London
Riconoscimento di “Eccellenza Clinica” - Clinical Excellence Award St Peter’s Hospital
Bilinguismo Italiano - Tedesco: Patentino A - Provincia Autonoma di Bolzano

ATTUALE RUOLO
Attualmente lavora come Consultant Stroke Physician, Stroke Medicine Department
Responsabile servizio di telemedicina degli ictus cerebrali nella contea (Provincia) del Surrey
St Peter’s Hospital, Guildford road, Chertsey, UK

Pubblicazioni:

  1. Grasso, R., Schena, F., Gulli, G., and Cevese, A. Does low-frequency variability of heart period reflect a specific parasympathetic mechanism?, J.Autonom.Nerv.Syst. 63: 30-38, 1997.
  2. Cevese, A., Gulli, G., Polati, E., Gottin, L., and Grasso, R. The baroreflex and the oscillation of heart period at 0.1 Hz studied by a-blockade and cross-spectral analysis in healthy humans, J.Physiol.(Lond). 531: 235-244, 2001.
  3. Gulli, G., Wight, V. L., Hainsworth, R., and Cevese, A. Spectral and cross-spectral autoregressive analysis of cardiovascular variables in subjects with different degrees of orthostatic tolerance, Clin.Auton.Res. 11: 19-27, 2001.
  4. Terziotti, P., Schena, F., Gulli, G., and Cevese, A. Post-exercise recovery of autonomic cardiovascular control: a study by spectral and cross-spectral analysis in humans, Eur.J.Appl.Physiol. 84: 187-194, 2001.
  5. Gulli, G., Cemin, R., Pancera, P., Menegatti, G., Vassanelli, C., and Cevese, A. Evidence of parasympathetic impairment in patients with cardiac syndrome X, Cardiovasc.Res., 2001.
  6. Giosuè Gulli, Victoria Louise Cooper, Victoria Claydon, Roger Hainsworth. Cross-spectral analysis of cardiovascular parameters whilst supine may identify subjects with poor orthostatic tolerance. Clin Sci (Lond). 2003 Jul;105(1):119-26.
  7. Gulli, G., Cevese, A., Cappelletto, P., Gasparini, G., Schena, F. Moderate aerobic training improves autonomic cardiovascular control in older women. Clin Auton Res. 2003 Jun;13(3):196-202.
  8. Gulli G, Cooper VL, Claydon VE, Hainsworth R. Prolonged latency in the baroreflex mediated vascular resistance response in subjects with postural related syncope. Clin Auton Res. 2005 Jun;15(3):207-12.
  9. Gulli G, Fattor B, Marchesi M. Cross-spectral analysis of cardiovascular variables in supine diabetic patients. Clin Auton Res. 2005 Apr;15(2):92-8.
  10. Gulli G, Cooper VL, Claydon VE, Hainsworth R. R-R interval-blood pressure interaction in subjects with different tolerances to orthostatic stress. Exp Physiol. 2005 May;90(3):367-75.
  11. Appenzeller O, Claydon VE, Qualls C, Slessarev M, Gulli G, Zenebe G, Hainsworth R. Cerebral Vasodilatation to Exogenous Nitric Oxide; a Marker of Fitness for Human Life at Altitude. Stroke 2006;37:1754-1758
  12. Gulli G, Claydon VE, Slessarev M, Zenebe G, Gebremedhin A, Rivera-Ch M, Appenzeller O, Hainsworth R. Autonomic regulation to orthostatic stress in Highlanders. Comparison with sea-level residents. Exp Phys Mar;92(2):427-35
  13. Claydon VE, Gulli G, Slessarev M, Appenzeller O, Zenebe G, Gebremedhin A, Hainsworth R. Cerebrovascular responses to hypoxia and hypocapnia in Ethiopian high altitude Dwellers. Stroke; 2008 Feb;39(2):336-42
  14. Giosué Gulli; Sofia Khan; and Hugh S. Markus. Vertebrobasilar Stenosis Predicts High Early Recurrent Stroke Risk in Posterior Circulation Stroke and TIA. Stroke; August 1, 2009; 40(8): 2732 - 2737
  15. Cappellari M, Tomelleri G, Piovan E, Bovi P, Moretto G, Gulli G. Chronic fusiform aneurysm evolving into giant aneurysm in the basilar artery. Neurol Sci. 2011 May 24.
  16. Giosuè Gulli, Hugh S Markus. The use of FAST and ABCD2 scores in posterior circulation, compared with anterior circulation, stroke and transient ischemic attack. Journal of Neurology Neurosurgery and Psychiatry. 2012 Feb;83(2):228-9.
  17. Gulli G, Marquardt L, Rothwell PM, Markus HS. Stroke Risk After Posterior Circulation Stroke/Transient Ischemic Attack and Its Relationship to Site of Vertebrobasilar Stenosis: Pooled Data Analysis From Prospective Studies. Stroke. 2013 Mar;44(3):598-604
  18. Giosué Gulli, Cantor Tarperi, Antonio Cevese, Michele Acler, Giuseppe Bongiovanni and Paolo Manganotti. Effects of prefrontal repetitive transcranial magnetic stimulation on the autonomic regulation of cardiovascular function. Experimental Brain Research. 2013 Apr;226(2):265-71
  19. Cappellari M, Moretto G, Micheletti N, Donato F, Tomelleri G, Gulli G, et al. Off-label thrombolysis versus full adherence to the current European Alteplase license: impact on early clinical outcomes after acute ischemic stroke. J Thromb Thrombolysis. 2014 May;37(4):549-56
  20. Gulli G, Peron E, Ricci G, Formaglio E, Micheletti N, Tomelleri G, Moretto G. Yield of ultra-rapid carotid ultrasound and stroke specialist assessment in patients with TIA and minor stroke: an Italian TIA service audit. Neurol Sci. 2014 Dec;35(12):1969-75
  21. Gulli G, Rutten-Jacobs LC, Kalra L, Rudd AG, Wolfe CD, Markus HS. Differences in the distribution of stroke subtypes in a UK black stroke population - final results from the South London Ethnicity and Stroke Study. BMC Med. 2016 May 20;14:77
  22. Wiedermann CJ, Piccin A, Gulli G. Therapeutic Plasma Exchange in Patients with Neurologic Disorders: Insufficient Evidence to Support the Use of Hydroxyethyl Starch. Indian J Hematol Blood Transfus. 2017 Sep;33(3):445-447
  23. Han TS, Fry CH, Fluck D, Affley B, Gulli G, Barrett C, Kakar P, Patel T, Sharma S, Sharma P. Evaluation of anticoagulation status for atrial fibrillation on early ischaemic stroke outcomes: a registry-based, prospective cohort study of acute stroke care in Surrey, UK. BMJ Open. 2017 Dec 14;7(12):e019122. 24. Han TS, Lean ME, Fluck D, Affley B, Gulli G, Patel T, Barrett C, Kakar P, Sharma S, Sharma P. Impact of delay in early swallow screening on pneumonia, length of stay in hospital, disability and mortality in acute stroke patients. Eur J Clin Nutr. 2018 Mar 27.
  24. Han TS, Fry CH, Fluck D, Affley B, Gulli G, Barrett C, Kakar P, Patel T, Sharma S, Sharma P. Anticoagulation therapy in patients with stroke and atrial fibrillation: a registry-based study of acute stroke care in Surrey, UK. BMJ Open. 2018 Jul 11;8(7)
  25. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. FOCUS Trial Collaboration. Lancet. 2019 Jan 19;393(10168):265-274.
  26. Han TS, Gulli G, Affley B, Fluck D, Fry CH, Barrett C, Kakar P, Sharma S, Sharma P. New evidence-based A1, A2, A3 alarm time zones for transferring thrombolysed patients to hyper-acute stroke units: faster is better. Neurol Sci. 2019 Aug;40(8):1659-1665
  27. GOAL collaborators. Global Outcome Assessment Life-long after stroke in young adults initiative-the GOAL initiative: study protocol and rationale of a multicentre retrospective individual patient data meta-analysis. BMJ Open. 2019 Nov 14;9(11)
  28. Han TS, Fry CH, Gulli G, Affley B, Robin J, Irvin-Sellers M, Fluck D, Kakar P, Sharma S, Sharma P. Stroke. 2020 Feb;51(2):594-600. Prestroke Disability Predicts Adverse Poststroke Outcome: A Registry-Based Prospective Cohort Study of Acute Stroke.
  29. Morjaria JB, Omar F, Polosa R, Gulli G, Dalal PU, Kaul S. Bilateral lower limb weakness: a cerebrovascular consequence of covid-19 or a complication associated with it? Intern Emerg Med. 2020 Aug;15(5):901-905.
  30. Han TS, Gulli G, Fry CH, Affley B, Robin J, Fluck D, Kakar P, Sharma P. Adverse consequences of immediate thrombolysis-related complications: a multi-centre registry-based cohort study of acute stroke. J Thromb Thrombolysis. 2022 Jan;53(1):218-227
  31. Sharma S, Wood M, Gulli G. COVID-19-associated ischaemic stroke despite use of anticoagulation. BMJ Case Rep. 2021 Jul 29;14(7):e243741. doi: 10.1136/bcr-2021-243741. PMID: 34326115; PMCID: PMC8323371.
  32. Fluck D, Fry CH, Gulli G, Affley B, Robin J, Kakar P, Sharma P, Han TS. Association of risk of malnutrition with adverse outcomes and early support on discharge in acute stroke patients without prestroke disability: A multicenter, registry-based cohort study. Nutr Clin Pract. 2022 Oct;37(5):1233-1241.
  33. Han TS, Fry CH, Fluck D, Gulli G, Affley B, Robin J, Kakar P, Sharma P. Predicting Stroke Complications in Hospital and Functional Status at Discharge by Clustering of Cardiovascular Diseases a Multi-Centre Registry-Based Study of Acute Stroke. J Stroke Cerebrovasc Dis. 2022 Jan;31(1):106162
  34. Fluck D, Fry CH, Rankin S, Gulli G, Affley B, Robin J, Kakar P, Sharma P, Han TS. Comparison of characteristics, management and outcomes in hospital-onset and community-onset stroke: a multi-centre registry-based cohort study of acute stroke. Neurol Sci. 2022 Aug;43(8):4853-4862. doi: 10.1007/s10072-022-06015-w. Epub 2022 Mar 23

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